E ric Lefkofsky is a prolific American serial entrepreneur and investor based in Chicago who has co-founded a string of successful, publicly traded technology companies. His most famous venture is Groupon, the online daily deals marketplace he co-founded with Andrew Mason and Brad Keywell. Groupon became a cultural phenomenon and had a high-profile IPO in 2011.

Lefkofsky's entrepreneurial partnership with Brad Keywell has been incredibly fruitful, leading to the creation of several other billion-dollar companies. These include the freight logistics company Echo Global Logistics, the advertising software provider Mediaocean, and the industrial AI company Uptake Technologies. More recently, he co-founded and is the CEO of Tempus, a healthcare technology company that uses AI and genomic sequencing to personalize cancer treatment. Tempus has become his primary focus and has achieved a multi-billion dollar valuation.