W ayne Rothbaum is a self-made American biotech investor who has made a multi-billion dollar fortune through a series of highly successful, high-stakes investments in the pharmaceutical industry. He is the founder and managing partner of Quogue Capital, his private investment fund. He began his career on Wall Street and became a successful healthcare-focused hedge fund manager. He is known for his deep scientific knowledge and for taking a hands-on, activist approach with the companies in which he invests.

He has a reputation for being a brilliant but often abrasive and demanding investor who pushes his portfolio companies to achieve their full potential. His career has been marked by a string of spectacular successes. He was a key early investor in companies like Acerta Pharma, which was sold to AstraZeneca for $4 billion, and Gene-trak, another major success. His most significant recent home run was his investment in Kartos Therapeutics, a cancer drug developer that was acquired by Novartis in a massive deal. These successful exits have cemented his reputation as one of the most successful and feared investors in the biotech sector.